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First Time Edible Dosage Guide: 2.5 mg THC

Start with 2.5 mg of THC

A first edible dose is 2.5 mg of THC or less. Do not take more for at least 2 hours. Most licensed stores sell edibles in 5 mg or 10 mg pieces, so cut the piece.

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The FDA has not set a THC dose for edibles. The 2.5 mg figure comes from Health Canada and from state health agencies in the US.

Homemade Cannabis Edibles: Tips for Perfect Bites

Why edibles differ from smoking

The liver converts THC into 11-hydroxy-THC. That metabolite reaches the brain in larger amounts than inhaled THC. Onset is 30 to 90 minutes on an empty stomach, and up to 2 hours after a meal. Inhaled THC peaks in about 10 minutes.

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Dose ranges

  • 1 to 2.5 mg: threshold dose. Most people feel little.
  • 2.5 to 5 mg: standard range for a first use.
  • 5 to 10 mg: one legal serving in Colorado and California. Too high for a first use.
  • 10 mg and up: high dose. Risk of anxiety, nausea, and fast heartbeat.

Colorado and California cap edibles at 10 mg THC per serving and 100 mg per package.

Timeline for one 5 mg dose

  1. 0 to 30 minutes: no effect in most cases.
  2. 30 to 90 minutes: first effects.
  3. 2 to 4 hours: peak.
  4. 4 to 8 hours: decline.
  5. Up to 12 hours: residual effects in some people.

What changes your response

  • Body weight and tolerance.
  • Liver enzyme activity, mainly CYP2C9 and CYP3A4. Genetics affect both.
  • Food in the stomach. A heavy meal delays onset.
  • Alcohol. It adds impairment.
  • Other drugs and some prescriptions.

If the dose is too high

Symptoms include panic, fast heartbeat, nausea, and confusion. There is no antidote. CBD does not reverse THC effects in controlled studies. Sit or lie down. Drink water. Wait. Symptoms peak at 2 to 4 hours and fade after that.

Call Poison Control at 1-800-222-1222 for chest pain, vomiting that will not stop, or a child who ate an edible. Store edibles locked and out of reach of children and pets. US poison centers log thousands of edible calls each year, and children under 6 make up a large share of them.

Rules for the first time

  1. Buy from a licensed store with mg printed on the package.
  2. Eat a light meal first, not a large one.
  3. Take 2.5 mg. Wait 2 hours.
  4. Skip alcohol.
  5. Stay home. Do not drive.
  6. Write down the time and the mg.

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Read our complete guide: The Cannabis Handbook: Effects, Risks, and How to Buy Smartly